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微工程和纳米工程方法用于研究瘤生态系统

Mijin Kim¹, Magdalini Panagiotakopoulou¹, Chen Chen^1,2,3

¹Molecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.

Nature reviews. Cancer

|June 23, 2023

概括

先进的微流体设备,生物打印和纳米传感器为研究复杂的瘤微环境 (TME) 和其相互作用提供了新的途径. 这些技术有助于揭示治疗漏洞,并提供瘤生态系统的系统性视图.

科学领域:

生物医学工程生物医学工程
癌症生物学癌症生物学
纳米技术纳米技术

背景情况:

瘤细胞和微环境的相互作用对于癌症研究至关重要.
目前研究这些相互作用的方法有限.
了解瘤生态系统需要先进的技术方法.

研究的目的:

突出利用微流体设备,生物打印和芯片上器官来改善瘤生态系统理解的机会.
讨论纳米传感器在现场TME分析中的潜力.
为了弥合癌症生物学和工程社区.

主要方法:

用于建模TME相互作用的微流体设备.
生物打印和器官芯片技术用于现场测量.
纳米传感器用于实时监测TME参数.

主要成果:

微流体,生物打印和有机体能够更好地建模瘤生态系统.
纳米传感器可以提供有关化学梯度,酶活性和代谢/免疫特征的关键数据.
这些技术提供了对瘤生态系统和潜在的治疗漏洞的系统视图.

结论:

生物医学技术如微流体,生物打印和纳米传感器对于促进癌症研究至关重要.
这些工具可以扩展癌症生物学中的方法,并激发新的工程方法.
使用这些技术对癌症生态系统进行审讯,有望对瘤生物学和治疗策略有更深入的见解.

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The Tumor Microenvironment

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