酒精消费可能与老年人手术后妄想有关:PNDABLE研究
Xiaoyue Wu1, Ning Zhang1, Bin Zhou2
1Department of Anesthesiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), 5, Dong-Hai Middle Road, Shi-Nan District, 266000, Qingdao, China.
BMC anesthesiology
|June 23, 2023
概括
酒精消费是老年人手术后妄想症 (POD) 的重要危险因素,特别是每日摄入量较高. 这项研究表明,酒精通过影响阿尔茨海默病相关生物标志物,如Aβ42.2,从而导致POD.
科学领域:
- 老年医学 老年医学
- 神经科学是一个神经科学.
- 麻醉学 麻醉学
背景情况:
- 手术后痴呆症 (POD) 是老年患者常见的并发症.
- 了解POD的风险因素对于预防和管理至关重要.
- 酒精消费的作用及其对POD神经退行性生物标志物的影响仍然是研究领域.
研究的目的:
- 调查酒精消费与老年人手术后狂妄症 (POD) 发生率之间的关联.
- 探索酒精消费,与阿尔茨海默病相关的脑脊液 (CSF) 生物标志物和POD之间的关系.
- 评估酒精消费和CSF生物标志物对POD的预测效果.
主要方法:
- 来自PNDABLE研究队列的252名老年患者的分析.
- 使用MMSE和POD诊断使用CAM和MDAS评估手术前的认知状态.
- 逻辑和线性回归,调解分析和ROC曲线构造以评估关联和预测能力.
主要成果:
- 发生POD的发生率为17.5%.
- 酒精消费被确定为POD的一个显著风险因素 (OR=1.016,P<0.001).
- 酒精消费与CSF Aβ42 (β=-0.638,P<0.001) 有负相关性,这表明POD发展中介 (14.21%).
结论:
- 酒精消费,特别是每天超过24克,是老年人POD可修改的风险因素.
- 酒精消费有助于POD,可能通过中介CSF Aβ42水平.
- 酒精消费在预测POD时表现出强大的歧视能力.
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