超过皮肤深度:内脏脂肪与牛皮病的疾病活性,功能和代谢指数密切相关
Tim Blake1,2, Nicola J Gullick3,4, Charles E Hutchinson4,5
1Department of Rheumatology, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK. timblakewarwick@gmail.com.
Arthritis research & therapy
|June 23, 2023
概括
与对照组相比,患有牛皮病 (PsD) 的患者体脂肪增加,包括内脏脂肪. 这种多余的脂肪与疾病活动,功能衰退和代谢问题相关,这表明内脏脂肪是治疗目标.
科学领域:
- 皮肤病学和风湿病学
- 医疗成像医学成像
- 代谢健康 代谢健康
背景情况:
- 牛皮病 (PsD),包括皮肤牛皮 (PsO) 和牛皮关节炎 (PsA),与全身炎症和代谢障碍有关.
- 了解PsD的身体组成变化对于全面的患者管理至关重要.
研究的目的:
- 为了比较PsD患者与对照者的身体组成.
- 调查PsD活动,功能状态和代谢健康之间的关联.
主要方法:
- 用自动化FatSegNet管道进行空气位移囊造影 (ADP) 和MRI评估的身体组成.
- 通过健康评估问卷 (HAQ) 测量功能状态.
- 代谢状态通过脂质谱,胰岛素和阿迪波内克水平来评估.
主要成果:
- 与BMI匹配的对照人群相比,PsD患者的MRI衍生体质参数,包括内脏脂肪组织 (VAT),更高.
- 身体脂肪和增值税的增加与不良的代谢标志物 (失脂症,胰岛素抵抗) 和更差的功能状态 (更高的HAQ) 相相关.
- 活跃的PsD显示出更明显的身体组成异常.
结论:
- 在PsD患者中,存在多余的脂肪组织,特别是代谢不良的内脏脂肪.
- 内脏脂肪与PsD的疾病活动,功能障碍和代谢障碍有关.
- FatSegNet提供了一种经过验证的工具,用于评估PsD中的脂肪细分;内脏脂肪可能是治疗目标.
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