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Updated: Jul 25, 2025

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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VarID2量化了基因表达噪声动态,揭示了衰老的造血干细胞的功能异质性

Reyna Edith Rosales-Alvarez1,2,3, Jasmin Rettkowski4,5, Josip Stefan Herman1

  • 1Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany.

Genome biology
|June 23, 2023
PubMed
概括

生物噪音,或基因表达的变异性,驱动细胞分化. 一个新的工具,VarID2,在单细胞分辨率下量化了这种噪音,揭示了以前隐藏在细胞转录组分析中的动态.

关键词:
年龄化 衰老 衰老细胞度的变异性基因表达噪声 基因表达噪声造血干细胞 造血干细胞 造血干细胞机器学习是机器学习.数学建模的数学建模单细胞RNA测序的一个细胞.干细胞分化 干细胞分化

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