系统性免疫炎症指数的动态变化是口腔癌患者的风险因素:一个病例控制研究和额外的HPV状态亚组分析
XiaoChuan Gan1, QiTao Gou1, Jing Zhu2
1Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong, Chongqing, 400016, China.
European journal of medical research
|June 23, 2023
概括
动态系统性免疫炎症指数 (SII) 的变化为口腔癌提供了比静态水平更好的预后预测,特别是在人类乳头瘤病毒 (HPV) 阴性患者中. 持续高的SII表明一个糟糕的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 口腔癌的预后是复杂的.
- 人类乳头瘤病毒 (HPV) 感染状态是一个关键因素.
- 系统性炎症的作用需要进一步研究.
研究的目的:
- 调查口腔癌中动态系统性免疫炎症指数 (SII) 的预后价值.
- 评估SII,HPV状态和患者结果之间的相互作用.
- 为了确定动态SII变化是否优于静态测量来预测预后.
主要方法:
- 对131名口腔癌患者的回顾性分析.
- 在治疗后大约9个月计算SII.
- 基于动态SII水平和HPV感染状态的预后的比较.
主要成果:
- 持续高的SII与预后不佳相关.
- 动态SII提供了比静态SII更全面的预测洞察力.
- 在HPV阴性患者中,不利的动态SII和舌根瘤位置预测了无病生存率的下降.
- 在这项研究中,没有确定HPV阳性患者的预后因素.
结论:
- 动态SII是口腔癌的更强大的预后指标,特别是在HPV阴性病例中.
- 在HPV阴性患者中不良的动态SII趋势可能需要更密切的监测或加强治疗策略.
- 对动态炎症标记物的进一步研究可以完善口腔大癌的管理.
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