儿童和青少年的结核病预防治疗偏好
M Strauss1, D T Wademan2, A Mcinziba2
1Health Economics and HIV and AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, South Africa.
概括
了解患者对结核病预防治疗 (TPT) 的偏好是改善其使用的关键. 儿童,青少年和护理人员优先考虑药物负担,味道,副作用和临床等待时间,以有效实施TPT.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 制药科学 制药科学
背景情况:
- 预防性结核病治疗 (TPT) 对于全球结核病消除工作至关重要.
- 目前的TPT实施面临挑战,尽管扩大了资格和新的制度.
- 了解患者和护理人员的偏好对于成功的TPT扩展至关重要.
研究的目的:
- 调查儿童,青少年和护理人员对结核病预防治疗 (TPT) 的偏好.
- 确定影响儿童和青少年群体中TPT选择和遵守的关键因素.
- 为制定以患者为中心的TPT交付策略提供信息.
主要方法:
- 在南非开普敦,对131名儿童,170名青少年和173名护理人员进行了一项离散选择实验.
- 还对17名参与者进行了深入采访,以收集定性见解.
- 用混合效应物流回归模型分析数据.
主要成果:
- 药丸的特性 (数量,大小,味道) 和副作用显著影响了儿童和照顾者的偏好.
- 临床等待时间和副作用是青少年和护理人员的主要因素.
- 青少年更喜欢当地诊所而不是社区服务,并且对剂量频率和治疗持续时间敏感,与更少的访问有关.
结论:
- 仅仅是较短的TPT疗程可能无法改善吸收和完成,而不考虑患者的偏好和医疗服务提供.
- 开发与儿童和青少年偏好相一致的TPT交付模型和配方是优先事项.
- 整合以患者为中心的方法对于提高TPT在终止结核病方面的有效性至关重要.
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