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Updated: Jul 25, 2025

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大型图书馆对接新型SARS-CoV-2主要蛋白酶非共价和共价抑制剂

Elissa A Fink1,2, Conner Bardine1,3, Stefan Gahbauer1

  • 1Department of Pharmaceutical Chemistry, University of California-San Francisco, San Francisco, California, USA.

Protein science : a publication of the Protein Society
|June 24, 2023
PubMed
概括

研究人员选了数十亿个分子,以找到SARS-CoV-2的新抑制剂.

关键词:
这就是SARS-COV-2病毒.发现对抗病毒的停泊.主要蛋白质酶的主要蛋白质酶.基于结构的抑制剂.

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Protein-Drug Binding: Mechanism and Kinetics01:16

Protein-Drug Binding: Mechanism and Kinetics

Protein-drug binding refers to the interaction between drugs and proteins within the body. This binding process can occur intracellularly, involving drug interactions with enzymes or receptors within cells, or extracellularly, involving plasma proteins in the blood.
Various forces drive these interactions, including hydrogen bonds, hydrophobic interactions, ionic bonds, electrostatic interactions, and van der Waals forces. These bonds enable drugs to bind to specific sites on proteins,...
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