EDEN (心电图辐射深度导航):一种新的方法来导航心脏肌肉内部的导航
Christopher G Bruce1, D Korel Yildirim2, Aravindan Kolandaivelu3
1Cardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: https://twitter.com/ChrisGBruce13.
一个新的工具,电心电图辐射深度导航 (EDEN),准确地指示心肌内的导线深度. 这一创新使新的导管心脏手术能够切割,重塑和切除心脏组织.
科学领域:
- 心血管研究的心血管研究.
- 医疗器械创新 医疗器械创新
- 电子生理学 电子生理学
背景情况:
- 内心肌导线导航允许导管在心室肌肉内移动.
- 使用标准成像来确定导线辐射深度是一项挑战.
研究的目的:
- 开发电心电图辐射深度导航 (EDEN),用于指示导线辐射深度的工具.
- 通过常规成像来促进新的心脏内导管程序.
主要方法:
- 在猪模型中映射了心内肌电图.
- 识别了辐射深度依赖的电图特征.
- 开发了一种用于位置指示和in silico建模的机器学习分类器.
主要成果:
- 伊甸园在心室壁和隔膜中确定了5个不同的深度区域.
- ST-段的高度大小有效地区分了位置.
- 机器学习分类器实现了97%的准确性;EDEN指导的MIRTH腹腔整形术.
结论:
- EDEN提供了一种简单,可重复的实时导线辐射深度评估方法.
- 伊甸园使得新的透导管内心肌内疗法,如MIRTH和SESAME.
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