在出现双侧手综合征或多个触发数字的老年患者中隐藏的粉样蛋白沉积
Aaron M Gray1, Amit C Patel2, F Thomas D Kaplan1
1Indiana Hand to Shoulder Center, Indianapolis, IN.
The Journal of hand surgery
|June 24, 2023
概括
粉样性粉症可能被诊断为老年人双边手掌道综合征或多个触发指. 推进行突膜活检,以便在高危患者中早期检测.
科学领域:
- 整形外科手术 整形外科手术
- 类风湿病学 类风湿病学
- 病理学 病理学 病理学
背景情况:
- 氨基粉症的诊断对于及时干预和预防并发症至关重要.
- 手腕道综合征 (CTS) 和触发指 (TD) 是潜在的粉样化症的早期指标.
- 识别更高风险的特定患者群体可以提高早期检测率.
研究的目的:
- 为了确定双边CTS和/或多重TD的患者中粉样粉症的患病率.
- 评估双边CTS和多个TD的联合存在是否会增加氨基粉症诊断率.
- 评估与粉样蛋白沉积相关的人口和临床因素.
主要方法:
- 预期招收男性>50岁和女性>60岁的双边CTS,多个TD或两者.
- 使用刚果红色染色方法分析样样样本的样样样本.
- 收集和分析人口和医疗共变量.
主要成果:
- 56名患者中有9人 (16%) 的测试结果为粉样蛋白沉积呈阳性.
- 粉样蛋白阳性和粉样蛋白阴性组表现出相似的人口统计和并发症.
- 30名双边CTS患者中的4名和17名多重TD患者中的4名的测试结果为粉样蛋白阳性.
- 在多次TD患者中,只有男性呈阳性,平均年龄更小 (61岁对73岁).
结论:
- 手部外科医生应考虑对50岁以上的男性和60岁以上的女性进行双边CTS.
- 在同一个年龄组的多个TD患者中,应考虑进行延膜活检.
- 该研究没有发现同时患有这两种疾病的患者的粉样蛋白发现率增加.
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