在2型糖尿病患者中,与夜间和白天血糖变异相关的因素:一个横截面研究

相关实验视频

Updated: Jul 25, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

319

J Jiang^1,2, Z Xia³, D Zheng^3,4

¹Department of Endocrinology, Jining No. 1 People's Hospital, 6 Jiankang Road, Rencheng District, Jining, 272000, Shandong, China.

Journal of endocrinological investigation

|June 24, 2023

概括

在2型糖尿病中,血糖变化 (GV) 在夜间和白天之间存在差异. 年龄,12 AM葡萄糖和肝酶影响夜间GV,而胰岛素敏感性和分泌影响昼间GV.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
糖尿病研究研究糖尿病研究

背景情况:

血糖变化 (GV) 是糖尿病管理的关键因素,但影响夜间和白天GV的因素仍未得到充分研究.
了解这些因素对于优化2型糖尿病血糖控制策略至关重要.

研究的目的:

调查2型糖尿病患者在夜间和白天期间与血糖变化 (GV) 相关的临床因素.
确定管理葡萄糖波动的潜在治疗点.

主要方法:

一项涉及134名2型糖尿病患者的横截面研究.
持续血糖监测 (CGM) 用于记录24小时的血糖变化.
血糖标准偏差 (SDBG),变化系数 (CV) 和血糖偏差 (MAGE) 的平均幅度被计算来评估GV. 强大的回归和受限制的立方线被用于分析.

主要成果:

夜间GV与年龄和12AM血糖水平积极相关,与氨酸转移酶负相关.
白天GV与HOMA2-S积极相关,与ISSI2.2负相关.
在12 AM血糖水平和MAGE之间,以及在ISSI2和GV指标之间观察到非线性关联,确定了切断点.

结论:

在2型糖尿病中,不同的临床因素会影响在夜间和白天期间的血糖变化.
确定了睡眠前血糖水平和胰岛素分泌敏感度指数-2 (ISSI2) 的切断点,可以作为改善β细胞功能和血糖控制的治疗点.

关键词:

剂量与反应的关系.血糖的可变性血糖的可变性影响因素影响因素.2型糖尿病是什么? 2型糖尿病是什么?

相关概念视频

01:22

Diabetes Mellitus: Type 2 and Gestational

2.6K

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

2.6K

01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

01:15

Diabetes: Symptoms, Diagnosis, and Complications

605

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...

605

01:16

Insulin: Dosing Regimen and Adverse Effects

214

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...

214

01:22

Diabetes Mellitus: Overview and Type I Subtype

2.8K

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

2.8K

01:36

Carbohydrate Metabolism

11.3K

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...