肥胖个体的肝脏参与:来自西印度的横截面研究
Minal Shastri1, Vaishnavi M Rathod2, Darshankumar M Raval3
1Professor.
The Journal of the Association of Physicians of India
|June 24, 2023
概括
肥胖会增加肝脏疾病的风险,特别是在老年妇女和那些久坐不动的生活方式. 关键指标包括高C反应蛋白 (CRP) 和受损的脂质配置文件,突出代谢综合征作为主要的危险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 公共卫生
背景情况:
- 肥胖是一个日益严重的全球健康问题,特别是在发展中国家.
- 它是非酒精性脂肪性肝病 (NAFLD) 的重要危险因素,是慢性肝病的主要原因.
- 中部肥胖症在NAFLD的发展中起着至关重要的作用,可能导致晚期肝脏疾病.
研究的目的:
- 研究各种风险因素和实验室标志物与肥胖个体肝脏参与之间的关联.
- 为了确定肥胖人口中NAFLD的预测因素.
主要方法:
- 一项涉及210名肥胖患者 (≥18岁) 的横截面研究在印度西部进行.
- 数据收集包括病史,体检,实验室测试和超声波来评估肝脏状况.
- 分析了风险因素和生物化学参数,以确定它们与肝脏疾病的相关性.
主要成果:
- 肝脏参与的危险因素包括年龄>50岁,女性性别,绝经后状态,久坐的生活方式,高BMI,腰围 (WC) 和子周围.
- 升高的C-反应蛋白 (CRP),SGOT,甘油三,LDL,胆固醇,FBS,PP2BS和低的HDL,血清蛋白和白蛋白与肝脏疾病有显著的关联.
- 高的NAFLD纤维化和BMI,氨基转移酶比率和糖尿病 (BARD) 评分,以及代谢综合征 (MS) 表示风险更高.
结论:
- 年龄的增长,女性的绝经后状态和身体不活动是肥胖个体肝脏疾病的风险因素.
- 升高的CRP和SGOT,以及异常的脂质样本和血糖控制,可以作为肥胖症中脂肪肝的标志物.
- 代谢综合征显著放大了肥胖患者肝脏参与的风险.
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