在精神分裂症中的海马体子场体积中改变的性别差异
Claudia Barth1,2, Stener Nerland1,2, Kjetil N Jørgensen2,3
1Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Schizophrenia bulletin
|June 24, 2023
概括
与对照人群相比,精神分裂症中的海马体积缺陷在男性中比女性更大. 这些大脑结构变化的性别差异是精神分裂症谱系障碍的特征.
科学领域:
- 神经成像是一种神经成像.
- 神经解剖学是一个神经解剖学.
- 精神病学是一个精神病学.
背景情况:
- 海马是一个关键的大脑结构,表现出基于性别的差异,并与精神疾病有关.
- 以前的研究表明,海马体形态在不同性别之间以及与心理健康状况相关的变化.
研究的目的:
- 为了研究海马体子场体积的性别和诊断组差异.
- 探索与健康对照组 (CTL) 相比,精神分裂症谱系障碍 (SZ) 和双相情感障碍 (BD) 患者的这些差异.
主要方法:
- 对1521名参与者 (SZ,BD,CTL) 进行了T1权重磁共振成像 (MRI).
- 使用Freesurfer软件估计了海马和子场体积.
- 统计分析检查了按性别诊断的群体相互作用和与临床/认知措施的关联.
主要成果:
- 在多个海马体子领域观察到显著的性别对群体的相互作用,包括总海马体,牙状圈和CA4.4.
- 与女性患者和同性对照患者相比,精神分裂症男性患者的体积学缺陷更大.
- 在SZ和BD中,海马体积与临床或认知措施之间的关联中没有发现显著的性别差异.
结论:
- 这项研究揭示了精神分裂症中海马子子子场的形态性差异的改变模式.
- 这些变化主要是由与对照人群相比,精神分裂症男性体积缺陷较大.
- 这些发现突显了精神分裂症中性别特异的神经解剖学变化.
相关概念视频
01:29Biological Causes of Schizophrenia
104
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
104
01:19Role of Hippocampus in Memory
352
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
352
01:17Schizophrenia
150
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
150
01:30Negative and Cognitive Symptoms of Schizophrenia
97
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
97