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神经类固醇敏感性的性别和季节性差异预测西伯利亚仓鼠的领土侵略性

Kathleen M Munley¹, David M Sinkiewicz², Sydney M Szwed³

¹Department of Biology, Indiana University, Bloomington, IN 47405, USA; Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405, USA; Department of Psychology, University of Houston, Houston, TX 77204, USA.

Hormones and behavior

|June 24, 2023

概括

黑色素通过改变大脑的类固醇敏感性来影响子的季节性侵略. 这些效应显示了神经基因表达和行为的性别特异性模式.

科学领域:

神经内分泌学神经内分泌学
行为神经科学行为神经科学
季节性生物学季节性生物学

背景情况:

动物生理学和行为的季节性变化,包括侵略性,已经得到了充分的证据.
桃激素的美拉托尼因涉及到通过类固醇激素调节西伯利亚仓鼠的季节性侵略.
精确的神经机制连接黑激素,类固醇和侵略性仍然在很大程度上不具特征.

研究的目的:

为了研究黑激素在雄性和雌性西伯利亚仓鼠中对类固醇敏感性和攻击性行为的神经作用.
检查光周期和黑激素治疗对大脑关键区域中类固醇酶和受体的基因表达的影响.

主要方法:

雄性和雌性西伯利亚仓鼠被安置在长日 (LD) 或短日 (SD) 光周期下,并在10周内接受黑激素或对照注射.
攻击性行为被量化.
使用定量PCR测量了芳酶,5α-减少酶3和雌激素受体1的相对mRNA表达在中间预视区域 (MPOA),前垂体 (AH),弧形核 (ARC) 和周水管灰 (PAG) 中.

主要成果:

无论是LD-氨酸治疗还是SD治疗,都增加了男性和女性的侵略性,ARC中的基因表达变化类似.
在MPOA,AH和PAG中观察到黑激素和SDs对基因表达的性别特异性影响.
在实验条件下,男性和女性在神经基因表达和侵略之间表现出明显的关系.

结论:

黑素在调节神经类固醇敏感性和攻击性的季节性变化方面发挥着重要作用.
独特的神经内分泌路径有助于雄性和雌性仓鼠的类似季节性侵略表型.
这项研究强调了特定于性别的神经对光周期和黑激素信号的反应.

关键词:

生物节奏生物节奏雌激素受体的受体是什么黑色素是什么黑色素是什么黑色素是什么这是神经类固醇.季节性是季节性的类固醇性酶类固醇性酶.领地性领地性

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