高精制碳水化合物饮食对肠道完整性的影响
Kátia Anunciação Costa1, Marina Chaves de Oliveira2, Letícia Maria de Souza Cordeiro1
1Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Nutrition (Burbank, Los Angeles County, Calif.)
|June 24, 2023
概括
高碳水化合物 (HC) 饮食诱导小鼠轻度肥胖与代谢变化. 然而,这种饮食并没有显著改变小肠的完整性,透性或细菌转移.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 代谢研究研究 代谢研究
背景情况:
- 由于营养摄入过多而导致的肥胖症涉及脂肪组织扩张和代谢功能障碍.
- 高脂肪饮食是已知的与肠道疾病相关的肥胖模型,但高精制碳水化合物 (HC) 饮食对轻度肥胖和肠道的影响不太清楚.
- 肠道屏障对肠道健康至关重要,可以受到饮食成分的损害,可能增加透性和细菌转移.
研究的目的:
- 研究高精制碳水化合物 (HC) 饮食对小肠完整性及其相关变化的影响.
- 为了确定HC饮食引起的轻度肥胖是否会影响肠道屏障功能,包括透性和细菌转移.
主要方法:
- 雄性BALB/c小鼠在8周内接受了标准食或高精制碳水化合物 (HC) 饮食.
- 评估体重增加,脂肪和代谢变化.
- 评估了小肠的参数,包括小长度,紧结蛋白表达,炎症标志物 (干扰素-γ,髓氧化酶,瘤亡因子-α) 和内皮淋巴细胞.
主要成果:
- 接受HC饮食的小鼠表现出增加的脂肪和代谢变化,尽管与对照组相比,体重增加没有显著差异.
- 在HC饮食小鼠的小肠中观察到高的干扰素-γ和髓氧化酶水平.
- 在肠长度,紧结表达 (zonula occludens-1,claudin-4),瘤缩因子-α水平,内皮细胞,肠透性或细菌转移方面没有发现显著差异.
结论:
- 摄入高精制碳水化合物 (HC) 饮食可能导致轻度肥胖和相关的代谢变化.
- 尽管代谢发生了变化,但HC饮食并没有损害小肠的完整性,透性或促进这种模型中的细菌转移.
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