在意大利的Omicron BA.1波中获得的COVID-19后,嗅觉和味觉功能障碍的恢复
Paolo Boscolo-Rizzo1, Giancarlo Tirelli1, Pierluigi Meloni2
1Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
American journal of otolaryngology
|June 24, 2023
概括
与COVID-19相关的嗅觉和味觉损失在Omicron BA.1感染的6个月内显著改善. 疫苗接种缩短了嗅觉和味觉功能障碍的持续时间,表明了有利的恢复率.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 嗅觉和味觉功能障碍是SARS-CoV-2感染的突出症状.
- 奥米克朗BA.1亚型导致报告的嗅觉和味觉障碍的减少.
- 关于与Omicron相关的化学感官功能障碍的长期影响的数据有限.
研究的目的:
- 为了确定自我报告的化学感官功能障碍的患病率,在SARS-CoV-2感染后6个月.
- 评估在意大利奥米克朗BA.1流行期间嗅觉和味觉功能障碍的恢复率.
- 评估疫苗接种对化学感知障碍持续时间的影响.
主要方法:
- 在意大利的大学医院和高等推中心进行了前性观察研究.
- 使用中鼻结局工具22 (SNOT-22),特别是"嗅觉或味觉"项目.
- 数据收集包括基线评估和6个月后续访谈.
主要成果:
- 在338名患有轻度至中度COVID-19的患者中,101名 (34.4%) 在基线报告了气味或口味的改变.
- 在6个月后,只有4名 (1.4%) 患者报告持续的功能障碍,96.0%的人经历了完全的解决.
- 接种疫苗的患者的嗅觉或味觉障碍持续时间显著缩短 (p=0.007).
结论:
- 在Omicron BA.1亚变体波中感染的患者表现出更有利的从化学感官功能障碍中恢复率.
- 在绝大多数受影响个体中,在6个月内观察到嗅觉和味觉障碍的完全消失.
- 接种疫苗对康复产生了积极的影响,导致嗅觉和味觉功能障碍的持续时间缩短.
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