手握强度,体力活动和发生轻度认知障碍和痴呆症
André O Werneck1, Raphael H O Araujo2, Danilo R Silva3
1Center for Epidemiological Research in Nutrition and Health, Department of Nutrition, School of Public Health, Universidade de São Paulo, São Paulo, Brazil.
Maturitas
|June 24, 2023
概括
定期体育活动与轻度认知障碍的风险降低有关. 增加握力,可能通过炼来增强,也降低了痴呆和轻度认知障碍的风险.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 轻度认知障碍 (MCI) 和痴呆症是严重的公共卫生问题.
- 识别可改变的认知衰退风险因素对于预防策略至关重要.
研究的目的:
- 研究手握强度在体力活动和认知能力下降之间的关系中的调解作用.
- 检查中等到剧烈的体力活动与发生的MCI和痴呆症之间的关联.
主要方法:
- 来自欧洲健康,老龄化和退休调查的19686名欧洲成年人 (平均年龄64.9岁) 的前性队列研究.
- 随访时间平均为10.2年,评估身体活动,手握强度和认知状态 (MCI和痴呆症诊断).
- 采用调解和考克斯的比例危险模型,调整了各种共同变量.
主要成果:
- 适度至剧烈的体力活动 (≥1天/周) 独立地与较低的MCI发病率相关 (HR:0.85).
- 手握力增加10%与MCI风险降低6%和痴呆症风险降低5%相关.
- 手握强度部分介导了身体活动和MCI (17.9%介导) 之间的关联.
结论:
- 适度至剧烈的体力活动显示出对轻度认知障碍的独立保护性关联.
- 手握强度成为一个重要因素,部分介于体育活动的认知益处.
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