STING调节了HIF1A对促炎性巨细胞表型转化为自身免疫性心肌炎的转化

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Xiumeng Hua1, Mengni Bao2, Han Mo2

  • 1Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Road, Xi Cheng District, Beijing 100037, China; Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; The Cardiomyopathy Research Group at Fuwai Hospital.

International immunopharmacology
|June 24, 2023
PubMed
概括

干扰素基因刺激器 (STING) 通过通过缺氧诱导因子-1α (HIF1A) 激活巨细胞来驱动自身免疫性心肌炎. 向STING提供了一个潜在的治疗策略,用于心肌炎.

关键词:
这就是HIF1A.炎症 炎症是一种炎症.巨细胞是一个巨细胞.刺痛是一种刺痛.一种自身免疫性心肌炎.

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