内部桥接的纳米二氧化用于加载和释放稀溶性化合物
Marzieh Heidari Nia1, Lee D Wilson2, Ali Reza Kiasat3
1Department of Chemistry, University of Saskatchewan, 110 Science Place, Room 165 Thorvaldson Building, Saskatoon, SK S7N 5C9, Canada; Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada; Quebec Centre for Advanced Materials (QCAM) and Pulp and Paper Research Centre, McGill University, 3420 University Street, Montreal, QC H3A 2A7, Canada; Department of Chemistry, College of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Journal of colloid and interface science
|June 24, 2023
概括
研究人员开发了类似海的纳米结构化二氧化 (SNS) 颗粒,由芳香交叉连接器连接,用于药物输送. 这些响应pH的SPS-DOX纳米复合材料显示出对癌症治疗和其他应用的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 开发用于向药物输送的新型纳米载体对于提高治疗疗效至关重要.
- 基于的纳米结构为各种应用提供生物相容性和可调节性质.
研究的目的:
- 为了设计一种新的类似海的纳米结构化 (SNS) 合物.
- 用一种芳香交叉连接器来使SNS功能化,用于药物封装.
- 评估产生的纳米复合材料 (SPS-DOX) 作为对pH反应的纳米载体的潜力,用于对乳腺癌细胞进行多克索鲁比的输送.
主要方法:
- 类似海的纳米结构化 (SNS) 颗粒的合成.
- 通过希夫基反应,通过SNS与bis(propyliminomethyl) (b(PIM) B-S进行交叉链接.
- 在位置内将多克索鲁比辛 (DOX) 纳入交联结构 (SPS-DOX).
- 对pH反应药物释放和生物相容性的评估.
主要成果:
- 成功合成了类似海的单分散纳米结构 (SNS) 颗粒.
- 在SNS中引入芳香交叉链接剂b(PIM) B-S,形成SPS纳米复合材料.
- 从SPS-DOX.证明了对pH反应的多克索鲁比 (DOX) 的加载和释放.
- 证实了SPS纳米复合材料的生物相容性.
结论:
- SPS纳米复合材料代表了一种独特的合物,具有类似海的结构.
- 作为一种生物相容,对pH值有反应的纳米载体,SPS-DOX对 doxorubicin 输送具有有前途的潜力.
- 潜在的应用包括先进的药物输送,废水整治和催化.
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