描述PSP-理查森综合征和血管帕金森症患者的步态和探索神经形态学
Koustav Chatterjee1, Subhadip Paul2, Rebecca Banerjee1
1Department of Neurology, Institute of Neurosciences Kolkata, 185/1 AJC Bose Road, Kolkata, 700017, India.
Parkinsonism & related disorders
|June 24, 2023
概括
区分渐进性超核性 (PSP) 和血管帕金森症 (VaP) 的步态是具有挑战性的. 与VaP相比,PSP患者表现出更大的步态变化和明显的神经解剖学差异,包括边缘结构.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 运动障碍 运动障碍
背景情况:
- 基于步态来区分渐进性上核性 (PSP) 和血管性帕金森症 (VaP) 是临床上具有挑战性的.
- 这两种疾病都有帕金森症的症状,因此需要客观标志物来准确诊断.
- 对于这两种情况来说,了解行走障碍的潜在神经解剖学相关性至关重要.
研究的目的:
- 为了比较患有PSP理查森综合征 (PSP-RS) 和VaP.患者之间的特定时空步态参数.
- 为了分析PSP-RS和VaP队列之间的大脑结构的神经形态学差异.
- 调查这些患者群体中步态变化和神经解剖学指数之间的关联.
主要方法:
- 招募了18名PSP-RS患者和13名VaP患者.
- 通过FreeSurfer管道通过GAITRite®和神经解剖学形态测量评估时空步行参数.
- 采用未配对的t测试与排列测试,控制UPDRS-III和H&Y分数,并应用Benjamini-Hochberg FDR进行多次比较.
主要成果:
- 与VaP相比,PSP-RS患者的步行时间,步行时间,摇摆时间和姿势时间的变化明显更大.
- 形态测量分析显示了下丘脑和尾骨体积,以及PSP-RS与VaP中的小脑皮层,海马体,杏仁体,accumbens和putamen体积的较高.
- 与PSP-RS相比,在VaP中双边岛屿显著较薄.
结论:
- 步行变化模式和特定的神经解剖学变化在PSP-RS和VaP之间有所不同.
- 相关性分析表明,边缘结构和小脑参与PSP-RS中的姿势控制和步态.
- 这些发现强调了检查个别大脑区域的重要性,以了解PSP-RS和VaP的步态变异性,这表明边缘系统参与超出了经典的运动控制结构.
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