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暴露于空气污染对子宫上微生物群落的影响
Inumidun H Oyebode1, Allan C Just2, Jacques Ravel3
1University of Pennsylvania, Philadelphia, PA, USA.
Environmental research
|June 24, 2023
概括
空气污染,特别是细颗粒物 (PM2.5),与阴道细菌群体 (CST IV) 相关,与早产风险有关. 这种暴露可能部分解释了CST IV流行中的种族差异.
科学领域:
- 环境健康 环境健康
- 微生物组研究 微生物组研究
- 生殖流行病学 生殖流行病学
背景情况:
- 阴道微生物群落,以社区状态类型 (CST) 为特征,影响生殖健康.
- 社区状态型IV (CST IV),以无氧细菌为主,是自发早产 (sPTB) 的风险因素.
- 在CST IV流行中存在种族差异,与白人相比,黑人的发病率更高,以及对空气污染的差异暴露.
研究的目的:
- 量化暴露于细颗粒物 (PM2.5) 和CST IV的流行率之间的关联.
- 调查PM2.5暴露中的种族差异是否有助于CST IV流行中的种族差异.
主要方法:
- 从母性和微生物组研究中对566名参与者的二次分析.
- 使用集成卫星和地面监测数据的机器学习模型估计PM2.5暴露.
- 通过16S rRNA测序从宫阴道拭子中确定的CST;进行多变量逻辑回归和调解分析.
主要成果:
- 增加的PM2.5暴露与CST IV的更高几率显著相关.
- 与白人参与者相比,黑人参与者呈现出更高的PM2.5中位数暴露率和更高的CST IV流行率.
- 调解分析表明,PM2.5暴露可能只占CST IV中黑白差异的很小但很大一部分.
结论:
- 微粒颗粒物 (PM2.5) 暴露与CST IV有关,这是自发早产的已知风险因素.
- 像PM2.5这样的环境因素可能在延续阴道微生物组合的种族健康差异方面发挥作用.
- 需要进一步的研究来阐明环境暴露,阴道微生物组和不良出生结果之间的联系机制.
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