STING通过干扰素独立的途径加强宿主抗汉塔病毒免疫力
Kerong Wang1, Jian Zhang2, Yongheng Yang2
1College of Life Sciences, Northwest University, Xi'an 710069, China; Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.
Virologica Sinica
|June 24, 2023
概括
干扰素基因刺激器 (STING) 途径限制了汉坦病毒 (HTNV) 复制,而不依赖于I型干扰素. 通过RIG-I和自性激活STING提供了一种针对汉塔病毒感染的新型治疗策略.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 汉坦病毒 (HTNV) 通过抑制I型干扰素 (IFN) 反应来逃避天生的免疫力.
- 除了IFN信号传递之外,宿主细胞对抗汉塔病毒的机制在很大程度上仍未被探索.
研究的目的:
- 调查干扰素基因刺激器 (STING) 在对HTNV的抗病毒免疫力中的作用.
- 阐明涉及STING介导的HTNV复制限制的分子途径.
主要方法:
- 研究了HTNV诱导的RIG-I激活和内质网膜 (ER) 应激 (IRE1-XBP1通路).
- 检查了HTNV感染期间STING的亚细胞局部化和激活.
- 评估了STING和Rab7A在触发自的相互作用.
- 在体内使用裸体小鼠模型评估了STING调制的保护作用.
主要成果:
- 感染HTNV通过ER压力激活RIG-I,导致STING转位和激活.
- STING与Rab7A相互作用以诱导自,限制HTNV复制.
- 对HTNV的STING的抗病毒活性独立于正规的I型IFN信号传输.
- 药理学STING调节剂在体内没有显示任何治疗益处.
- 缺少其C端尾部 (ΔCTT) 的STING突变的外源表达在裸体小鼠中提供了对致命的HTNV感染的保护.
结论:
- 确定了一种新的RIG-I-STING-自途径,对于限制HTNV至关重要.
- 证明了STING对汉塔病毒的IFN独立抗病毒功能.
- 这一途径为汉塔病毒感染提供了潜在的治疗点.
相关概念视频
Immune Response Against Viral Pathogens
830
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
830
Antimicrobial Proteins
1.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.1K
Antigens Involved in Adaptive Immunity
563
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
563
Cell-mediated Immune Responses
69.1K
Overview
69.1K
siRNA - Small Interfering RNAs
16.9K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.9K
Viruses with RNA Genomes
58
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
58


