儿童的铁状况和心脏代谢风险
Milton Fabian Suárez-Ortegón1, Anna Prats-Puig2, Judit Bassols3
1Departamento de Alimentación y Nutrición, Pontificia Universidad Javeriana Seccional Cali, Cali, Colombia; Grupo de Ciencias Básicas y Clínicas de la Salud, Pontificia Universidad Javeriana Seccional Cali, Cali, Colombia.
Diabetes research and clinical practice
|June 24, 2023
概括
儿童的低铁状况与较高的HbA1c和代谢综合征 (MetS) 风险有关. 较高的费里水平与其他心脏代谢标记物有关,受炎症和体重的影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养生物化学 营养生物化学
- 代谢健康 代谢健康
背景情况:
- 代谢综合征 (MetS) 是儿童群体日益关注的一个问题.
- 铁的状态,通过血清费里和转激素表明,在各种生理过程中发挥作用.
- 了解儿童的铁状况和MetS成分之间的关系对于早期干预至关重要.
研究的目的:
- 调查血清费里和转激素水平与儿童代谢综合征 (MetS) 变量之间的关联.
- 为了检查与基线铁状况相关的MetS组件的纵向变化.
主要方法:
- 一项纵向研究涉及832名年龄在3-14岁的青春期前儿童.
- 一组203名儿童在平均随访3.7年后再次接受检查.
- 结果包括MetS,MetS成分,糖化血红蛋白 (HbA1c),以及它们随时间的变化.
主要成果:
- 较低的费里丁水平独立地与增加的HbA1c Z分数和血糖症有关.
- 转林水平与透静血压和胰岛素抵抗相关 (HOMA-IR).
- 在基线费里水平最低的儿童中,在随访期间,MetS风险得分恶化;更高的费里与其他MetS标志物有关,但这些关联在调整后减弱了.
结论:
- 儿童的铁水平降低与血糖控制和MetS独立相关.
- 较高的费里水平与其他心脏代谢风险因素有关,受炎症,肝功能和体重的影响.
- 需要进一步的研究来确定这些发现是否代表早期风险或正常发育变化.
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