探索肠道微生物群与学龄前儿童的全面智力之间的关联
Marcel van de Wouw1, Laura Rojas1, Elnaz Vaghef-Mehrabani1
1Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Neuroscience letters
|June 24, 2023
概括
这项研究探讨了肠道微生物组及其与学龄前儿童认知能力的联系. 在口语理解和肠道微生物多样性和素水平之间发现了负相关性.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
背景情况:
- 肠道微生物群-大脑轴是一个不断增长的研究领域,但人类研究显示出不一致的结果.
- 很少有研究研究了肠道微生物代谢物作为神经认知结果的潜在媒介.
研究的目的:
- 调查全面智力 (FSIQ) 与学龄前儿童肠道微生物群和代谢组之间的关联.
- 探索特定神经认知指数与肠道微生物组成和代谢物之间的关系.
主要方法:
- 分析了来自阿尔伯塔怀孕结果和营养 (APrON) 队列的245名典型发育儿童 (3-5岁) 的便样本.
- 使用16S rRNA测序评估便微生物组,使用LC-MS/MS测序评估代谢组.
- 使用韦克斯勒学前和小学智力尺度-IV (WPPSI-IV) 测量神经认知,包括FSIQ,口头理解,视觉空间和工作记忆指数.
主要成果:
- 语言理解与香农α多样性的负相关性 (r = -0.14,p = 0.032).
- 语言理解也与咖啡因衍生的代谢物帕拉丁负相关 (r = -0.22,p < 0.001).
- 在肠道微生物群/代谢物和神经认知指标之间没有发现其他显著的关联.
结论:
- 微弱到适度的相关性表明,在学龄前儿童的肠道微生物多样性,素水平和口语理解之间存在潜在的,有限的关联.
- 需要进一步的研究来阐明肠道微生物组与神经发育之间的复杂相互作用.
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