无法抑制头部旋转期间的萨卡德测试作为临床生物标志物认知功能障碍在帕金森病的临床生物标志物
Jung Hwan Shin1, Dong Ah Shin2, Chan Young Lee1
1Department of Neurology, Seoul National University Hospital & Seoul National University College of Medicine, Seoul, South Korea.
Neuroscience letters
|June 24, 2023
概括
在萨卡德测试期间不自发地旋转头部可能表明帕金森病 (PD) 的认知功能障碍. 这种头部运动生物标志物在检测PD患者的认知障碍方面表现出很高的准确性.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 认知科学 认知科学
背景情况:
- 认知功能障碍是帕金森病 (PD) 的一个常见问题.
- 需要可访问的临床生物标志物来检测PD的认知障碍.
- 在摇摆测试期间不自发的头部运动正在作为潜在的生物标志物被探索.
研究的目的:
- 为了研究非自愿的头部旋转在摇摆测试中作为PD认知功能障碍的潜在生物标志物.
- 评估头部旋转指标和认知功能得分之间的相关性.
主要方法:
- 27名PD患者和9名健康对照参与了这项研究.
- 一个陀螺仪测量了头部在摇摆测试期间的旋转.
- 蒙特利尔认知评估 (MoCA) 用于认知评估.
- 相关性分析检查了头部旋转和MoCA分数之间的关系.
主要成果:
- 头部旋转的峰值角速度与MoCA得分显著相关 (R = -0.52,p = 0.0023).
- 头部旋转值 (5°/s和10°/s) 与MoCA得分有显著的相关性.
- 头部旋转生物标志物显示出100%的积极预测值和认知障碍的特异性 (MoCA <26).
结论:
- 无法抑制头部旋转的过程中,可以作为一个潜在的临床生物标志物.
- 这种方法为在帕金森病中选认知功能障碍提供了一个有希望的方法.
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