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Mariele Bevilaqua¹, Maria Carolina Widholzer Rey², Gian Carlo Antonini Cappellini³

¹Department of Dermatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil; Universidade Luterana do Brasil, Canoas, RS, Brazil.

Anais brasileiros de dermatologia

|June 24, 2023

概括

瘤炎症透物 (TII) 存在于所有薄型初级皮肤黑色素瘤 (TPCM),无论转移. 这项研究无法证实TII.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
病理学病理学病理学

背景情况:

瘤炎症透 (TII) 通常与皮肤黑色素瘤转移的风险降低有关.
然而,其在薄型原发性皮肤黑色素瘤 (TPCM) 中的作用仍然不清楚,没有确立的共识.

研究的目的:

为了确定TPCM中TII的流行率.
调查TII与TPCM患者转移的发展之间的关联.

主要方法:

对50名TPCM患者进行了病例控制研究.
患者被分为转移性 (MC,n=22) 和非转移性 (NMC,n=28) 组.
评估了TII的存在和强度 (轻度,中度,明显).

主要成果:

在所有50个研究的TPCM病例中都检测到了TII.
在转移和非转移组之间没有观察到TII存在或强度的显著差异 (p=0.503).
多变量分析没有确定中度或显著的TII对转移的统计学上显著的保护作用.

结论:

在TPCM中,TII是一个普遍的发现,无论转移状态如何.
这项研究仅限于小样本,因此无法就TII在TPCM转移中的保护作用得出明确的结论.
需要对更大的队列进行进一步的研究,以澄清TII在TPCM中的预后意义.

关键词:

生物标志物生物标志物淋巴细胞,入瘤的透细胞黑色素瘤是一种黑色素瘤.新生体转移的转移.预测预后预测预测

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