增加晚期早产风险和在暴露于热应激后改变子宫血流
Dennis Yüzen1, Isabel Graf2, Ann-Christin Tallarek3
1Department of Obstetrics and Fetal Medicine, Laboratory for Experimental Feto-Maternal Medicine, University Medical Centre of Hamburg-Eppendorf, Germany; Institute of Immunology, University Medical Centre of Hamburg-Eppendorf, Germany.
EBioMedicine
|June 24, 2023
概括
高环境温度增加了早产风险,特别是在34-37周的怀孕期间. 温带气候地区的孕妇需要加强对热应激的产前监测.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 气候变化和健康问题
背景情况:
- 气候变化和热量暴露对人类健康构成重大风险,特别是对孕妇来说.
- 由于生理变化和对后代的潜在长期影响,孕妇是一个脆弱的群体.
- 对温带气候中热应激影响的研究有限,适应力可能较低.
研究的目的:
- 为了研究热应激和在温带气候下早产之间的联系.
- 为了确定关键的暴露时间和病理生理机制,将热和早产联系起来.
主要方法:
- 追溯分析来自德国汉堡的42,905个单身出生记录 (1999-2021年).
- 将出生数据与气象数据相匹配,以根据温度和湿度百分比来定义基于温度和湿度百分比的热事件.
- 利用来自预期队列 (n=612) 的超声波数据来探索病理生理学原因.
主要成果:
- 极端和长时间的热量暴露都显著增加了早产的相对风险.
- 在妊娠34-37周之间确定了暴露于热量的关键窗口,从而增加了晚期早产的风险.
- 女胎儿更容易受到与热应激相关的早产,并观察到子宫动脉血管抵抗的改变.
结论:
- 温带地区的热压力是早产的重要危险因素.
- 这些地区的产前护理方案应更新,包括积极监测与热有关的风险.
- 这些发现强调了需要有针对性的干预措施,以减轻怀孕期间暴露于热量的影响.
相关概念视频
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Homeostatic Imbalances in Body Temperature
159
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
159
Pathophysiology of Diabetes
1.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.0K
Factors Affecting Body Temperature
4.5K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
4.5K
Psychoneuroimmunology: Cardiovascular Disease
54
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
54
Responses to Heat and Cold Stress
13.6K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.6K


