使用婴儿兄弟姐妹设计来探索自闭症和ADHD特征之间的关联在试验者和年轻兄弟姐妹的气中
Linn Andersson Konke1, Terje Falck-Ytter2,3,4,5, Emily J H Jones6
1Department of Psychology, Uppsala University, Box 1225, 751 42, Uppsala, Sweden. linn.andersson.konke@psyk.uu.se.
Journal of autism and developmental disorders
|June 24, 2023
概括
老兄弟姐妹的自闭症和ADHD特征与特定的婴儿气质差异有关. 遗传因素可能会影响婴儿兄弟姐妹的早期行为,从而提供对神经发育状况的见解.
科学领域:
- 发展心理学 发展心理学
- 行为遗传学 行为遗传学
- 神经发育障碍 神经发育障碍
背景情况:
- 自闭症谱系障碍 (ASD) 和注意力缺陷/多动性障碍 (ADHD) 是复杂的神经发育状况.
- 了解早期行为标志物对于及时干预和支持至关重要.
- 婴儿兄弟姐妹设计是研究对神经发育的遗传和环境影响的宝贵工具.
研究的目的:
- 调查自闭症和ADHD的试验 (索引case) 特征是否预测婴儿兄弟姐妹的气质.
- 确定婴儿气质特征与自闭症和ADHD特征有何差异的程度.
- 探索遗传责任在早期出现的行为中的作用.
主要方法:
- 利用婴儿兄弟姐妹设计,使用来自BASIS (英国) 和EASE (瑞典) 队列的216对兄弟姐妹.
- 收集了父母对自闭症和ADHD特征的评分 (康纳斯评分表-3) 在较大的兄弟姐妹 (年龄419).
- 在9个月大时评估婴儿兄弟姐妹的气质特征 (婴儿行为问卷 - IBQ).
主要成果:
- 在控制共变量后,在试验特征和婴儿气质之间发现了特定的,适度的关联.
- 试验和自闭症特征与较低的婴儿接近有关,部分由婴儿发育水平解释.
- 试验和ADHD特征与更高的婴儿活动水平有关,独立于共变量.
结论:
- 普朗德自闭症和ADHD特征提供了关于婴儿兄弟姐妹气质的预测信息.
- 遗传责任可能会影响婴儿兄弟姐妹早期行为的发展.
- 这些发现突出了通过气质评估早期识别神经发育风险的潜力.
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