ALDH2 rs671和MTHFR rs1801133的多态性是多动脉动脉硬化风险因素
Nan Cai1,2, Cunren Li3,4, Xianfang Gu3,4
1Center for Cardiovascular Diseases, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, China. cn527257@163.com.
BMC cardiovascular disorders
|June 24, 2023
概括
特定的基因变异,即ALDH2 rs671 A/A和MTHFR rs1801133 T/T,与多动脉动脉硬化风险增加有关. 这些发现突出了心血管疾病的潜在遗传标志物.
科学领域:
- 遗传学和分子生物学
- 心血管研究研究心血管研究
- 医学科学 医学科学 医学科学
背景情况:
- 多重动脉的动脉硬化是心血管事件的重要危险因素.
- 乙甲脱酶2 (ALDH2) 和甲基基酸减少酶 (MTHFR) 是关键酶,参与血管内皮细胞内的氧化还原反应,影响动脉样硬化.
- 在ALDH2和MTHFR基因中的多态性与血管疾病的发病有关.
研究的目的:
- 调查ALDH2 rs671和MTHFR rs1801133基因多态化与多动脉动脉硬化存在的关联.
- 确定这些特定基因变异是否是多动脉动脉硬化症的独立风险因素.
主要方法:
- 进行了一项病例控制研究,涉及410名单动脉动脉硬化患者和472名多动脉动脉硬化患者.
- 进行了ALDH2 rs671和MTHFR rs1801133多态的基因定型.
- 使用后勤回归分析来评估基因型和多动脉动脉硬化症之间的关系,并根据临床共变量进行调整.
主要成果:
- 与单个动脉疾病相比,在多动脉动脉硬化患者中,ALDH2 rs671 A等位基和MTHFR rs1801133 T等位基的比例明显更高.
- 具有ALDH2 rs671 A/A基因型的个体显示出更高的酒精消费史的流行率.
- 后勤回归确定了ALDH2 rs671 A/A基因型 (OR 1.996) 和MTHFR rs1801133 T/T基因型 (OR 1.943) 作为多动脉动脉硬化的独立危险因素.
结论:
- ALDH2 rs671 A/A基因型和MTHFR rs1801133 T/T基因型可以作为影响多个动脉的动脉硬化发展的独立风险因素.
- 这些遗传多态化需要进一步研究它们在心血管风险分层中的作用.
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