代谢功能障碍相关的脂肪肝疾病和发作性心力衰竭风险:凯卢安队列研究
Zhihao Wei1, Zhe Huang2, Zongshuang Song1
1School of Public Health, North China University of Science and Technology, Tangshan, 063210, China.
Diabetology & metabolic syndrome
|June 24, 2023
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 显著增加心力衰竭 (HF) 的风险. 患有MAFLD和2型糖尿病的人面临更高的风险,需要更密切的医疗照顾.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 建议代谢功能障碍相关的脂肪肝疾病 (MAFLD) 取代NAFLD,强调其与代谢问题的联系.
- MAFLD是心肌梗塞和中风的独立风险因素.
- MAFLD与心力衰竭 (HF) 之间的关联需要进一步调查.
研究的目的:
- 调查MAFLD与患心力衰竭 (HF) 的风险之间的关系.
主要方法:
- 2006年,从凯卢安队列中选择了一个由98,685名没有高频率的参与者组成的队列.
- 根据诊断标准,参与者被分为非MAFLD和MAFLD组.
- 考克斯回归分析用于评估MAFLD对HF风险的影响,平均随访时间为14.01年.
主要成果:
- 与非MAFLD组 (2.19/1000人/年) 相比,MAFLD组的HF发病率密度更高 (3.29/1000人/年).
- MAFLD与HF风险增加1.40倍相关 (HR: 1.40,95% CI: 1.30-1.50).
- 患有MAFLD和2型糖尿病的个体显示HF的风险明显更高 (HR: 1.95,95%CI: 1.73-2.20).
结论:
- MAFLD是心力衰竭的重要危险因素.
- 在MAFLD患者中脂肪肝疾病的恶化与HF风险增加有关.
- 应特别注意具有同时存在2型糖尿病的MAFLD患者.
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