居住在组织中的虫与肠道微生物群之间的相互作用驱动粘膜免疫调节
Yugui Wang1,2, Aijiang Guo2,3,4, Yang Zou2,4
1College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, 030801, China.
NPJ biofilms and microbiomes
|June 24, 2023
概括
肠外虫感染可以通过促进调节性T细胞 (Tregs) 来减少结肠炎. 肠道细菌,特别是Lactobacillus reuteri,是这种宿主-虫-细菌相互作用的关键媒介,促进抗炎作用.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 寄生虫学的寄生虫学
背景情况:
- 居住在组织中的虫调节宿主免疫力,经常促进调节性T细胞 (Tregs) 和改变肠道微生物群.
- 肠道微生物群在非肠道寄生虫的免疫调节作用中的特定作用仍然在很大程度上是未知的.
研究的目的:
- 研究宿主,肠外虫 (幼虫 Echinococcus multilocularis) 和肠道细菌在调节结肠Tregs中的三方关系.
- 阐明肠道微生物群对虫感染引起的抗炎反应有所贡献的机制.
主要方法:
- 使用了幼虫 Echinococcus multilocularis 感染的小鼠模型.
- 采用便微生物群的枯竭和移植来评估肠道细菌的作用.
- 进行了肠道微生物组的枪元基因组和代谢分析.
- 研究了特定细菌菌株,如Lactobacillus reuteri,对Treg种群的影响.
主要成果:
- 在老鼠中,幼虫E. multilocilocularis感染减轻了结肠炎和增加了结肠Foxp3+Treg群体.
- 肠道微生物群对于虫诱导的Treg扩张至关重要.
- 感染导致肠道微生物组结构发生了显著的变化,特别是乳酸菌reuteri的增加.
- 微生物的新陈代谢被重新编程,以产生更多的短链脂肪酸,已知的Treg调节剂.
- 升高的L. reuteri水平足以促进结肠Treg频率.
结论:
- 肠外虫感染通过调节肠道微生物群驱动宿主结肠Tregs的扩张.
- 肠道微生物群作为抗炎作用的关键调解者,即使在涉及肠外虫的治疗中也是如此.
- 这突显了肠道微生物群在宿主-寄生虫相互作用和潜在的治疗策略中的重要性.
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