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Updated: Jul 25, 2025

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与精神分裂症相关的NRXN1缺失诱导了人类大脑器官的发育时间和细胞类型特定的脆弱性

Rebecca Sebastian1,2, Kang Jin3,4, Narciso Pavon2

  • 1Graduate Program in Neuroscience & Behavior, UMass Amherst, Amherst, MA, 01003, USA.

Nature communications
|June 24, 2023
PubMed
概括

神经素-1 (NRXN1) 缺失会影响大脑发育和神经网络. 精神分裂症 (SCZ) 患者的背景揭示了神经前体和独特的分子特征的特定干扰,影响皮质发育.

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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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