皮肤黑色素瘤患者死亡原因:一项基于美国人口的研究
Mohammed Ahmed Sadeq1, Mohamed Hady Ashry2, Reem Mohammed Farouk Ghorab1
1Faculty of Medicine, Misr University for Science and Technology, 6th of October, Giza, Egypt.
Scientific reports
|June 24, 2023
概括
对于局部皮肤黑色素瘤 (CM),非癌症死亡比癌症死亡更为常见. 然而,与普通人群相比,晚期CM阶段显著增加了因所有原因死亡的风险.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 皮肤黑色素瘤 (CM) 患者的死亡结果,特别是非癌症死亡原因,研究不足.
- 了解与CM相关的全谱死亡风险对于全面的患者护理至关重要.
研究的目的:
- 为了确定患有恶性皮肤黑色素瘤的患者中非癌症相关死亡的患病率.
- 通过疾病阶段分层,将CM患者的各种原因死亡风险与美国普通人口进行比较.
主要方法:
- 从SEER数据库中利用了2000-2019年间诊断为CM的224,624名美国患者的数据.
- 根据诊断时的黑色素瘤阶段对患者进行分层,并计算出不同死亡原因的标准化死亡率 (SMR).
- 对比死亡风险与美国一般人口,以评估相对风险.
主要成果:
- 总死亡人数为60,110人 (26.8%);死亡率随着黑色素瘤阶段的增加而增加,远程疾病的死亡率达到80%.
- 在局部CM中,非癌症原因 (60.5%) 在黑色素瘤死亡 (25.8%) 上占主导地位.
- 在区域和远程阶段,黑色素瘤是导致死亡的主要原因. 心血管和脑血管疾病是最常见的非癌症原因. 局部化CM与普通人群相比没有增加非癌症死亡风险,与具有显著更高风险的区域/远程阶段不同.
结论:
- 非癌症原因是局部皮肤黑色素瘤死亡率的重要因素.
- 与一般人群相比,晚期皮肤黑色素瘤与因癌症和非癌症原因死亡的风险显著增加有关.
- 心血管和脑血管疾病代表了所有阶段的黑色素瘤患者的主要非癌症死亡风险.
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