血液学和其他实验室参数在COVID-19患者中的变化
Yasmeen Khatib1, Rashmi Samele2, Jayashri Chaudhari3
1Professor.
The Journal of the Association of Physicians of India
|June 25, 2023
概括
血液学,凝血和炎症标志物,如C-反应蛋白 (CRP) 和白蛋白-6 (IL-6) 可以预测COVID-19的严重程度和患者的结果. 这些易于获取的生物标志物有助于早期患者分类,以实现最佳管理.
科学领域:
- 传染性疾病 传染性疾病
- 临床病理学 临床病理学
- 免疫学 免疫学 免疫学
背景情况:
- 2020年3月,COVID-19被世界卫生组织宣布为大流行,呈现出广泛的疾病严重程度.
- 确定可靠的生物标志物对于评估COVID-19的严重程度和预测患者的结果至关重要.
- 以前的研究探讨了各种实验室参数,以衡量疾病的进展.
研究的目的:
- 分析患有轻度,中度,重度和危急COVID-19的患者的血液学,凝血和免疫学标志物.
- 研究这些标记物与COVID-19患者的整体结果之间的关系.
主要方法:
- 一项回顾性观察性研究包括1000名住院COVID-19患者.
- 根据世卫组织的指导方针,患者被分为轻度,中度,严重和关键组.
- 分析了血液学,凝血和炎症参数,并与疾病严重程度和存活率相关联.
主要成果:
- 增加的白细胞计数,绝对中性粒细胞计数 (ANC),中性粒细胞-淋巴细胞比率 (NLR),血小板-淋巴细胞比率 (PLR),C反应蛋白 (CRP),血清费里丁,乳酸脱酶 (LDH) 和IL-6) 与疾病严重程度的增加有关.
- 绝对淋巴细胞计数 (ALC) 的降低也与疾病严重程度有显著的相关性.
- 这些标志物在重症组之间显示出显著的差异,与患者的存活率相关.
结论:
- 几种血液学和炎症标志物作为重要的生物标志物用于预测COVID-19的预后和患者的结果.
- 这些标记物的可访问性允许早期患者分层和及时管理.
- 这些发现支持在COVID-19患者的临床决策中使用常规实验室参数.
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