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艾滋病毒阳性患者的神经认知障碍
Prateek S Padole1, Rupal N Padhiyar2, Dhirendra S Yadav3
1Ex-Senior Resident.
The Journal of the Association of Physicians of India
|June 25, 2023
概括
与艾滋病毒相关的神经认知障碍 (HAND) 在艾滋病毒阳性个体中很常见,超过70%的人受到影响. 年龄较大,教育程度较低,CD4计数较低增加了风险,影响了记忆力和语言流性.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 人类免疫缺陷病毒 (HIV) 相关的神经认知障碍 (HAND) 在HIV阳性个体中存在各种认知和功能障碍.
- 尽管有效的抗逆转录病毒疗法 (HAART),但HAND的患病率仍然很高,这给公共卫生带来了相当大的挑战.
研究的目的:
- 确定多民族艾滋病毒感染人口中HAND的流行率.
- 描述神经认知障碍,并确定与HAND相关的因素.
主要方法:
- 一项涉及孟买第三级护理中心250名艾滋病毒阳性患者的横截面研究.
- 使用国际艾滋病毒痴呆症量表 (IHDS) 和阿登布鲁克斯认知检查修订 (ACE-R) 评估认知功能.
- 排除标准包括狂妄症,已知的中枢神经系统或精神疾病以及怀孕.
主要成果:
- HAND的患病率为71.60%,无症状损伤为37.20%,轻度认知功能障碍为29.60%.
- 记忆力,语言流性和视觉空间能力是受影响最严重的认知领域.
- HAND患病率与年龄的增加 (p=0.020),与教育 (p<0.00) 的负相关,与CD4计数的最低值 (p<0.00) 的负相关.
结论:
- 艾滋病毒相关的神经认知障碍 (HAND) 在艾滋病毒阳性个体中非常普遍,通常呈现无症状.
- 年龄较大,教育程度较低,CD4计数较低是HAND的关键危险因素.
- 在这个人群中,认知缺陷通常会影响记忆力,语言流性和视觉空间能力.
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