与印度COVID-19患者相关的风险因素:单一中心回顾性队列研究
Darshana Rathod1, Ketan Kargirwar2, Mayur Patel3
1MD Internal Medicine, Additional Director.
The Journal of the Association of Physicians of India
|June 25, 2023
概括
这项研究确定了印度COVID-19死亡率的关键风险因素,包括老年,并发症和严重症状. 托西利祖马布治疗增加了死亡风险,而氧化加亚齐思罗米显示出潜在的益处.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 关键护理医学 关键护理医学
背景情况:
- 在全球范围内,COVID-19大流行已经造成了显著的死亡率.
- 确定医院内死亡风险因素对于患者管理至关重要.
研究的目的:
- 为了确定COVID-19患者在医院死亡的风险因素.
- 分析印度孟买一家三级护理医院的患者特征和结果.
主要方法:
- 对565名COVID-19患者进行了回顾性队列研究.
- 使用卡普兰-梅尔和考克斯比例危险模型进行生存分析.
- 逻辑回归用于风险因素的多变量分析.
主要成果:
- 8.7%的死亡率;20%需要ICU入院,58%的存活率.
- 与年龄 (≥60),高血压,透析,肺部疾病,喘息,严重的HRCT发现,ICU入院和低淋巴细胞数量相关的显著死亡风险.
- 托西利祖马布使用与较高的死亡率相关,而氧化 + 亚齐思罗米显示出有利的结果.
结论:
- 增加年龄,并发症和严重症状与更高的COVID-19死亡率有关.
- 免疫抑制治疗 (托西利祖马布) 可能会增加死亡风险.
- 氧化氨酸+阿齐思罗米在体外显示了潜在的抗病毒益处.
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