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关于艾滋病毒感染者代谢障碍的观察性研究

Pallab Sinha¹, Nandini Chatterjee², Souvik Ghatak³

¹Postgraduate Trainee.

The Journal of the Association of Physicians of India

|June 25, 2023

概括

针对HIV的抗逆转录病毒疗法 (ART) 可能导致代谢变化. 基于蛋白酶抑制剂的ART显著增加艾滋病毒感染者 (PLHIV) 的总胆固醇,甘油三和葡萄糖不耐受性.

科学领域:

传染性疾病传染性疾病
代谢障碍代谢障碍代谢障碍
药理学药理学是指药理学的学科.

背景情况:

艾滋病毒感染是一个全球性的健康挑战,在印度的流行率很高.
抗逆转录病毒疗法 (ART) 已经将艾滋病毒转化为可管理的慢性疾病.
在长期接受ART的艾滋病毒感染者 (PLHIV) 中,人们越来越多地认识到代谢并发症.

研究的目的:

为了评估两年多的PLHIV在ART上的代谢异常.
为了比较以前没有接受ART的患者与接受ART的患者的代谢概况.
评估基于蛋白酶抑制剂 (基于PI) 和非PI的ART对代谢健康的影响.

主要方法:

成年艾滋病毒阳性患者,既从未接受过ART,也接受过ART超过2年,都被纳入.
临床检查包括血压和人类测量测量.
实验室调查包括脂质特征 (总胆固醇,甘油三,HDL-C,LDL-C) 和葡萄糖水平 (禁食血葡萄糖,HbA1c).

主要成果:

基于PI的ART与与以前没有ART的个体相比,总胆固醇和甘油三水平显著更高.
没有接受过ART的患者表现出异常低的HDL-C的更高患病率.
在基于PI的ART组中,葡萄糖不耐受性明显更为普遍 (p<0.001).
在LDL-C,血压,BMI,腰围或CD4计数和ART疗法或HIV状态之间没有发现显著的关联.

结论:

总胆固醇,甘油三和葡萄糖水平是受PLHIV中ART影响的关键代谢参数.
基于PI的ART疗法与脂质障碍症和葡萄糖不耐症有着特别的联系.
可能需要进一步的研究,以有效地管理这些代谢障碍.

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