在认知衰退患者的个性化生活方式干预期间观察到认知能力的改善
Heather Sandison1, Nini G L Callan2, Rammohan V Rao3
1Solcere, Encinitas, CA, USA.
Journal of Alzheimer's disease : JAD
|June 25, 2023
概括
多模式治疗计划改善了客观认知障碍 (OCI) 患者的认知功能. 这种方法,结合生活方式的改变和营养支持,显示了管理阿尔茨海默病 (AD) 的认知衰退的希望.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 阿尔茨海默病 (AD) 的特点是逐渐的客观认知障碍 (OCI).
- 目前的单一疗法对阿尔茨海默病进展的影响有限,这表明其具有多因素性质.
- 为了有效的干预,可能需要采用多模式治疗策略.
研究的目的:
- 评估多式联络,个性化护理计划对OCI患者认知功能的影响.
- 根据对认知衰退的潜在贡献者,如营养和生活方式因素,评估认知表现的变化.
- 为了确定一个务实的,多元件干预的可行性和有效性.
主要方法:
- 来自加利福尼亚州圣地亚哥的34名OCI参与者的样本接受了多式联络干预.
- 干预包括改变生活方式 (饮食,运动,压力管理),营养品和药物.
- 在基线和一,三,六个月后使用剑桥脑科学 (CBS) 电池和蒙特利尔认知评估 (MoCA) 评估认知功能.
主要成果:
- 参与者在6个月后的MoCA分数显著改善,从19.6到21.7 (p=0.013).
- 在CBS记忆域和整体复合认知得分 (p<0.01和p=0.02,分别) 中注意到了显著的改善.
- 通过CBS电池评估的所有领域都表现出改善.
结论:
- 一个为期六个月的多式调节干预导致了多个领域的认知功能的可测量改善.
- 个性化,多模式的方法是可行的,并显示出对客观认知障碍的积极影响.
- 需要进一步的研究来探索这种治疗策略的长期影响和更广泛的适用性.
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