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Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
在2型糖尿病中,每周Icodec与每日Glargine U100相比,以前没有胰岛素
Julio Rosenstock1, Stephen C Bain1, Amoolya Gowda1
1From Velocity Clinical Research at Medical City (J.R.) and the Division of Endocrinology, Department of Internal Medicine, and the Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center (I.L.) - both in Dallas; Swansea University Medical School, Swansea, United Kingdom (S.C.B.); Novo Nordisk, Søborg, Denmark (A.G., B.L.); Servicio de Endocrinología y Nutrición, Hospital Universitario Quironsalud Madrid, Facultad de Medicina, Universidad Europea, Madrid (E.J.); Novo Nordisk, Tokyo (T.N.); Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo (R.T.), and the Department of Medicine and Surgery, University of Milano Bicocca, Milan (R.T.) - both in Italy; and the Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center (O.M.), and the Faculty of Medicine, Hebrew University of Jerusalem (O.M.) - both in Jerusalem.
在患有2型糖尿病的成年人中,每周一次的胰岛素icodec与每天一次的胰岛素glargine U100相比,显示出更好的血糖控制. 这种临床基础胰岛素模拟剂为糖尿病管理提供了一个有前途的新选择.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 胰岛素icodec是一种用于糖尿病管理的临床基础胰岛素.
- 2型糖尿病影响全球数百万人,需要有效的胰岛素疗法.
研究的目的:
- 为了评估每周一次的胰岛素icodec与每天一次的胰岛素glargine U100的疗效和安全性.
- 为了评估2型糖尿病的成年人的血糖控制,以前没有接受过胰岛素治疗.
主要方法:
- 进行了一项为期78周的随机,开放标签的3a期试验 (ONWARDS 1).
- 患有2型糖尿病的成年人 (HbA1c 7-11%) 被随机分配给接受胰岛素icodec或胰岛素glargine U100.
- 主要终点:52周HbA1c的变化;次要终点:血糖范围中的时间 (70-180 mg/dL).
主要成果:
- 胰岛素icodec在52周后显示HbA1c的平均降低更大 (-1.55%对-1.35%).
- 与icodec (71.9%与66.9%) 相比,在目标血糖范围中花费的时间显著增加.
- 记录了低血糖率,没有发现新的安全信号.
结论:
- 与每天一次的胰岛素glargine U100相比,每周一次的胰岛素icodec实现了更好的血糖控制.
- 胰岛素icodec是2型糖尿病基础胰岛素治疗的潜在有效和安全替代品.
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