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在功能性发作患者中,杏仁体子场和前额叶皮层异常

Nilab Nasrullah¹, Wesley T Kerr², John M Stern³

¹Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden; Neurology Clinic, Karolinska University Hospital, Stockholm, Sweden.

Epilepsy & behavior : E&B

|June 25, 2023

概括

功能性 (FS) 在杏仁体和海马体中显示出明显的神经解剖学变化. 功能性发作的这些发现可能有助于确定用于诊断和治疗的生物标志物.

科学领域:

神经成像是一种神经成像.
神经学神经学
精神病学是一个精神病学.

背景情况:

功能性 (FS) 呈现为类似的发作,没有潜在的活动,原因不明和与大脑相关.
以前的脑成像研究表明FS的大脑变化,但没有阐明病理生理学.
这项研究的重点是研究FS患者的杏仁体和海马体内的特定神经解剖学变化.

研究的目的:

研究具有功能性发作 (FS) 患者和前对照者 (SNC) 之间的杏仁体和海马体子区域的神经解剖学差异.
探索观察到的神经解剖学变化与慢性压力和抑郁症等疾病之间的潜在关联.
评估这些发现作为未来FS诊断和治疗的生物标志物的潜力.

主要方法:

对37名FS女性患者和37名年龄相匹配的女性SNCs的T1MRI扫描进行了回顾性分析.
使用FreeSurfer软件 (7.1版本) 详细分析整个大脑皮质厚度,皮质下体积和杏仁体/海马体子领域.
用多变量线性模型进行群组比较.

主要成果:

在FS和SNC组之间,杏仁体和海马体总体体积没有显著差异.
在FS患者中,右侧杏仁体体积显著减少,左上额头线变薄.
在FS组中观察到右侧中央和中间杏仁体,左侧前杏仁体和海马的左侧牙状圈的体积增加.

结论:

这项研究证实了功能性发作中杏仁体和海马体的神经解剖学关联.
观察到的体积和厚度变化模式与慢性压力和抑郁症中观察到的脑部变化保持一致.
进一步研究和验证这些神经解剖学发现可能会导致FS的诊断和治疗生物标志物的发展.

关键词:

阿米格达拉的一个桃体.慢性压力是一种慢性压力.皮层厚度皮层厚度在海马体内,海马体心理造成的非发作.

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