洞察氧胺酸改性多孔粉的结构-活性关系:氧基组的作用
Yunxiang Ma1, Ruixi Chen2, Zidi Chen2
1College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, Gansu, China; State Key Laboratory of Arid Land Crop Science, Gansu Agricultural University, Lanzhou 730070, China.
Food chemistry
|June 25, 2023
概括
改性粉的抗氧化能力取决于化学结构. 副替代的肉酸改性多孔粉 (p-CA@PS) 由于其结合结构,显示出更好的抗氧化活性.
科学领域:
- 食品化学 食品化学
- 聚合物科学 聚合物科学
- 有机化学 有机化学
背景情况:
- 粉的修改对于增强其功能性质至关重要.
- 氧胺酸以其抗氧化能力而闻名.
- 了解结构-活性关系是开发新型抗氧化剂的关键.
研究的目的:
- 为了合成和表征由酸 (CA) 和其元 (m-CA) 和副 (p-CA) 替代衍生物修饰的多孔粉 (PS) Ester.
- 为了评估这些改性粉的抗氧化能力.
- 研究化学结构对抗氧化剂活性的影响.
主要方法:
- 用肉酸,元替代的肉酸和副替代的肉酸对多孔粉进行化.
- 使用1HNMR,13C固态NMR和FT-IR光谱学进行表征.
- 通过DPPH激素清除,降解功率和基激素清除试验来评估抗氧化剂活性.
主要成果:
- 成功合成具有类似置换度的多孔粉 (CA@PS,m-CA@PS,p-CA@PS).
- 由于缺乏基基组,CA@PS表现出较弱的抗氧化活性.
- 与CA@PS和m-CA@PS相比,p-CA@PS的抗氧化能力更强.
- p-CA@PS的结合结构有助于产生更强的电子捐赠效应,增强其抗氧化能力.
结论:
- 酸酸改性粉的抗氧化能力受到其化学结构的显著影响.
- 基基的存在和替代位置起着至关重要的作用.
- 在肉酸衍生物中的副替代增强了改性粉的抗氧化活性.
相关概念视频
02:36Acidity and Basicity of Alcohols and Phenols
19.4K
Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.
19.4K
02:23Structure and Nomenclature of Alcohols and Phenols
17.5K
Overview
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds,...
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds,...
17.5K
02:32Physical Properties of Alcohols and Phenols
14.6K
Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of...
Alcohols possess a higher boiling point than aliphatic hydrocarbons of...
14.6K
01:16Adrenergic Agonists: Chemistry and Structure-Activity Relationship
3.1K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
3.1K
01:10Radical Reactivity: Steric Effects
1.9K
The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic...
Along with electronic...
1.9K
01:11ortho–para-Directing Activators: –CH3, –OH, –NH2, –OCH3
6.1K
All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
6.1K