执行控制功能障碍对帕金森病中步态结的贡献
Madli Bayot1, Kathy Dujardin2, Morgane Gérard1
1Univ. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Department of Clinical Neurophysiology, F-59000 Lille, France.
概括
执行功能障碍影响帕金森病 步态结 (FoG). 然而,注意力负荷并没有特别恶化FOG患者的步骤启动,这表明认知和步行之间存在复杂的联系.
科学领域:
- 神经科学是一个神经科学.
- 运动障碍 运动障碍
- 认知科学 认知科学
背景情况:
- 执行功能障碍被假设在帕金森病 (PD) 中导致步态结 (FoG).
- 注意力负荷对FOGPD患者步行启动的具体影响尚不清楚.
研究的目的:
- 研究注意力负荷对FOG和没有FOG的PD患者阶段启动的准备和执行阶段的影响.
- 在认知运动任务期间检查行为和皮层差异.
主要方法:
- 使用了一种适应的注意力网络测试 (ANT),以步骤启动作为响应.
- 在任务期间,在15名FoG患者,16名非FoGPD患者和15名对照中记录了动态,动态和高分辨率电脑电图 (EEG) 数据.
主要成果:
- 患有FOG的帕金森病患者表现出执行控制受损.
- 虽然PD患者的步骤执行时间较长,但执行控制对这一措施的影响在不同组之间没有差异.
- 在步骤启动期间与执行控制相关的皮质活动 (α和β脱同步) 在对照组和患者之间显示出差异,但执行控制对此活动的影响是相似的.
结论:
- 涉及解决冲突的注意力任务在所有组中同样改变了步骤启动和大脑活动.
- 执行控制,步行启动和FoG之间的关系似乎比以前假设的更复杂.
- 执行功能障碍可能与FOG有关,但不是唯一的原因因素,因为注意力和运动准备之间的相互作用没有直接诱导FOG.
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