在基于固体分散的配方中使用色素染料对Zafirlukast的离子对复合的光谱和统计参数的评估
Zeeshan Masood1, Muhammad Tayyab Ansari1, Samina Afzal1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
概括
这项研究开发了四种简单,快速和经济的分析方法,用于在固体分散配方中量化Zafirlukast (ZST). 这些新的方法提供了批量,固体分散和剂量形式的准确ZST估计.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 频谱光度测量是一种光谱光度测量.
背景情况:
- 像Zafirlukast (ZST) 这样的白三烯抗剂在治疗呼吸系统疾病方面至关重要.
- 药物配方中ZST的准确量化对于确保治疗疗效和患者安全至关重要.
- 现有的分析方法可能缺乏简单性,速度或日常分析的成本效益.
研究的目的:
- 开发和验证Zafirlukast (ZST) 的新,简单,无提取和经济的分析方法.
- 为了量化ZST在Meglumine和EudragitEEPO的固体分散配方中.
- 评估开发的方法的光谱和热力学特征.
主要方法:
- 开发了四种分析方法:一种是基于直接的HCl溶剂分析,另外三种是利用电荷转移复合物与烯醇蓝,乙醇蓝和烯醇绿进行分析.
- 在特定波长 (λmax) 上测量ZST的光谱测量.
- 根据ICH指南对方法进行统计优化和验证,包括回归分析和精度和准确性的评估.
主要成果:
- 开发了四种不同的分析方法 (A,B,C,D),在指定的度范围内具有线性.
- 确定了所有方法的酒法规,其度范围各不相同.
- 描述了光谱和热力学特性,包括摩尔吸收率,LOD,LOQ,关联常数和吉布斯自由能量 (ΔG°).
结论:
- 提出的分析方法简单,快速,经济,适合估计Zafirlukast (ZST).
- 这些方法适用于纯散装,固体分散和制药剂量形式的ZST量化.
- 开发的方法遵循ICH指南,确保可靠性和未来的分析实用性.
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