血清维生素D状况和伊朗老年人的认知功能:Birjand纵向衰老研究的证据
Ozra Barmaki1, Asieh Mansour2, Mitra Moodi3
1Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
The Journal of nutrition
|June 25, 2023
概括
这项研究发现,维生素D水平与老年人认知能力下降之间没有显著的联系. 在这个人群中,维生素D缺乏与认知功能受损无关.
科学领域:
- 老年学是一门学科.
- 营养神经科学 营养神经科学
- 流行病学 流行病学
背景情况:
- 新出现的证据表明,维生素D缺乏和认知能力下降之间存在联系.
- 然而,现有的研究提出了关于维生素D水平和认知障碍的异质发现.
研究的目的:
- 调查60岁及以上的成年人中维生素D缺乏和认知衰退之间的联系.
- 为了澄清血清25-氧维生素D [25(OH) D]度与老龄化人口的认知功能之间的关系.
主要方法:
- 从Birjand长度衰老研究 (BLAS) 的基线数据的横截面分析.
- 包括1219名年龄≥60岁的参与者.
- 使用6项认知障碍测试 (6-CIT),迷你精神状态检查 (MMSE),类别流利性测试 (CFT) 和缩写精神测试得分 (AMTS) 评估认知功能.
- 通过与酶相关的免疫吸收剂测定测量血清25(OH) D度,并使用多重逻辑回归分析相关性.
主要成果:
- 大多数参与者 (74.24%) 具有足够的维生素D水平 (≥20 ng/ml).
- 没有发现血清25(OH) D度和任何认知测试 (6-CIT,AMTS,MMSE,CFT) 的得分之间存在显著的相关性.
- 认知障碍的患病率与维生素D状况没有显著的关系.
结论:
- 这项研究发现,在老年人中,维生素D状态和认知障碍之间没有显著的关联.
- 维生素D缺乏或不足与该队列的认知功能受损无关,即使经过对混因素进行调整.
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