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Updated: Jul 25, 2025

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太赫兹时域光谱用于从滚筒压缩颗粒制成的片剂的研究

Moritz Anuschek1, Anne Linnet Skelbæk-Pedersen2, Thomas Kvistgaard Vilhelmsen2

  • 1Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark; ET Oral Product Development, Novo Nordisk A/S, Måløv, Denmark.

International journal of pharmaceutics
|June 25, 2023
PubMed
概括

太赫兹时域光谱 (THz-TDS) 可以监测在服用药片期间的药片孔隙性和颗粒大小变化. 一种新的校正方法改善了散射样本中的孔隙性预测,增强了过程控制.

关键词:
碎片化 碎片化颗粒化 颗粒化 颗粒化这就是PATAT PATAT.滚筒紧缩压缩机的使用方法散射分析是一种分散分析.药物使用 药物使用 药物使用太赫兹时间域光谱法

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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