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Yaotian Tian¹, Xinyang Li¹, Xiaonan Wang¹

¹Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 100730 Beijing, China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, 100730 Beijing, China.

Magnetic resonance imaging

|June 25, 2023

概括

三维胺质子转移 (APT) 成像检测了帕金森病 (PD) 的皮质变化. 这些与APT相关的参数显示出诊断潜力,作为非侵入性PD诊断的成像生物标志物.

科学领域:

神经成像是一种神经成像.
生物标志物生物标志物
帕金森病研究帕金森病研究

背景情况:

胺质子转移 (APT) 图像以前在帕金森病 (PD) 中使用专注于深核的二维技术证明了诊断和预测价值.
假设PD中的病理生理变化会改变大脑皮层内的APT相关参数.

研究的目的:

调查PD中的病理生理异常是否会改变大脑皮层中与APT相关的参数.
确定这些皮质信号变化是否可以帮助准确诊断PD.

主要方法:

34名患有异常性帕金森病 (IPD) 的患者和29名正常对照者 (NC) 接受了3D-APT和3D-T1WI成像.
使用SPM和MATLAB进行自动皮层细分和计算与APT相关的定量指标.
进行了统计比较 (t-test/Mann-Whitney U),相关性分析 (Spearman) 和诊断性能评估 (ROC,后勤回归).

主要成果:

在皮质APT信号和临床评估 (H&Y,疾病持续时间,UPDRS III,MMSE) 之间没有发现显著的相关性.
与NC相比,在IPD患者的灰质中观察到显著更高的MTRasym,CESTRnr和MTRRex值 (p < 0.001).
右灰质中的MTRRex显示出最高的诊断性能 (AUC:0.865),组合参数达到0.932.9的AUC.

结论:

3D-APT成像可以识别与帕金森病相关的大脑皮质变化.
与APT相关的参数的皮质变化可以作为非侵入性PD诊断的有价值的成像生物标志物.

关键词:

氨基胺质子转移成像成像布拉克的舞台是布拉克的舞台.化学交换和转移化学交换和转移帕金森病是帕金森病的一种.

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