在处理慢性疾病的随机对照试验中,患者和公众的参与度低于最佳水平
Mathilde Husson1, Agnès Dechartres2, Bruno Ramdjee1
1Département de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Paris 75013, France.
Journal of clinical epidemiology
|June 25, 2023
概括
在慢性疾病随机对照试验 (RCT) 中,患者和公众参与 (PPI) 是常见的,但往往有限. 在RCT中加强患者伙伴关系对于更好的研究成果至关重要.
科学领域:
- 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
- 患者参与 患者参与
背景情况:
- 患者和公众参与 (PPI) 在研究中越来越被认可.
- 了解慢性病随机对照试验 (RCT) 中PPI的程度和性质是很重要的.
- 之前的研究还没有完全详细说明PPI在慢性疾病RCT中的作用.
研究的目的:
- 描述慢性疾病随机对照试验 (RCT) 中患者和公众参与 (PPI) 的特征.
- 为了确定PPI是否与特定的试验特征有关.
主要方法:
- 在PubMed的搜索中,确定了在具有强制性PPI声明的期刊上发表的慢性疾病的RCT.
- 分析了101个RCT,以确定PPI的存在和阶段.
- 参与PPI的RCT的试验特征与没有PPI的RCT进行了比较.
主要成果:
- 在101个RCT中,40%报告了PPI,主要是在设计和实施阶段.
- 在制定或选择结果措施时,PPI的参与较少.
- 涉及PPI的RCT更有可能在BMJ发表,拥有英国作者,公共资金,更高的包容率,并评估数字干预,不太可能使用安慰剂对照.
结论:
- 在慢性病RCT中,PPI存在的比例很大,但往往处于低于最佳的阶段.
- 需要加强患者参与,作为慢性疾病的RCT的真正合作伙伴.
- PPI可能与特定的试验设计和报告特征有关.
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