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食中链脂肪酸通过GDF15-GFRAL轴在小鼠中减少食物摄入量

Josephine M Kanta¹, Luisa Deisen², Kornelia Johann³

¹The August Krogh Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.

Molecular metabolism

|June 25, 2023

概括

中链脂肪酸 (MCFA) 增加循环生长/分化因子15 (GDF15),这是一个关键的食欲调节剂. 对于MCFA来说,GDF15-GFRAL通路对于减少食物摄入量和体重至关重要.

科学领域:

营养科学营养科学
代谢过程中的代谢.
内分泌学在内分泌学.

背景情况:

中链脂肪酸 (MCFA) 减少食物摄入量,但机制尚不清楚.
MCFA被吸收到门静脉中,直接到达肝脏.
这种独特的吸收表明肝脏因素介于MCFA的食欲效应.

研究的目的:

研究MCFA减少食物摄入量的机制.
假设MCFA会触发肝因子,从而降低食欲.
确定参与MCFA诱导的食欲抑制的特定分子途径.

主要方法:

在口服MCFA后分析小鼠肝脏转录组.
在MCFA测量后测量了循环GDF15和Gdf15mRNA.
在缺乏GDF15或其受体GFRAL的小鼠中,评估了MCFA对食物摄入量和体重的影响.

主要成果:

摄入MCFA增加了肝脏和小肠Gdf15表达和循环GDF15.
与LCFA不同,MCFA在24小时内减少了食物摄入量.
对于MCFA的厌食效应和体重减轻,需要GDF15-GFRAL轴.

结论:

摄入MCFA是一种新的营养方法,可以增加循环GDF15.
GDF15-GFRAL轴对于MCFA的减食作用至关重要.
这项研究揭示了饮食脂肪在食欲调节中的新途径.

关键词:

食物摄入量食物摄入量增长/差异化因子 15 15 肝激素 (hepatokine) 是一种肝激素.脂质代谢脂质的代谢中链脂肪酸中链脂肪酸腹感是一种腹感.

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