在COVID-19疫苗接种后对T细胞和B细胞免疫类型和抗体反应的评估
Ritu Chadha1, Udayakumar Ds1, Rashmi Phogat2
1Medanta- The Medicity, Gurugram, Haryana, India.
Indian journal of medical microbiology
|June 25, 2023
概括
这项研究表明,COVISHIELD疫苗接种显著提高了SARS-CoV-2 IgG抗体水平,并改变了T和B细胞子集. 这些免疫反应对于维持对COVID-19感染的保护至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 了解对SARS-CoV-2疫苗接种的免疫反应对于管理COVID-19流行病至关重要.
- 科维希尔德是广泛使用的疫苗,其对幽默和细胞免疫的影响需要详细调查.
研究的目的:
- 在SARS-CoV-2疫苗接种后评估T和B细胞子集和IgG抗体水平 (COVISHIELD).
- 评估疫苗接种后不同时间点免疫反应的动态.
主要方法:
- 健康的成年人 (n=50) 接受了COVISHIELD疫苗接种.
- 接种疫苗前,接种疫苗后,接种疫苗后,接种疫苗后6个月的血液样本.
- 流细胞计分析了T和B细胞子集; 化学发光免疫测试量化了SARS-CoV-2 IgG抗体.
主要成果:
- 在接种疫苗后观察到SARS-CoV-2IgG水平的显著增加.
- 在T细胞子集的变化包括增加CD4原始和CD8原始T细胞,并减少CD4中央记忆T细胞.
- 预生殖中心B细胞显著增加,CD8效应记忆和CD8中央记忆T细胞显著减少.
结论:
- 幽默性 (抗体) 和细胞 (T和B细胞) 免疫力都对持续保护COVID-19后COVISHIELD疫苗接种的保护至关重要.
- 持久性T细胞子集甚至在抗体水平正常化时也可能有助于免疫力.
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