在伊索尼亚齐德单抗耐药性Mycobacterium tuberculosis从奥迪沙州分离出来的突变中InhA和KatG突变的模式
Sujeet Kumar1, Sunil Swick Rout1, Sarita Kar1
1National Reference Laboratory for TB, ICMR-Regional Medical Research Centre, Bhubaneswar, 751023, Odisha, India.
Indian journal of medical microbiology
|June 25, 2023
概括
耐异酸结核病 (Hr-TB) 影响了印度奥迪沙州1.53%的结核病菌株. 常见的katG和hA突变驱动这种耐药性,影响这种耐药结核病的治疗策略.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 仍然是一个全球卫生挑战,耐药性需要持续监测.
- 伊索尼亚兹是第一线抗结核病药物,耐药性严重复杂化了治疗方案.
- 了解异化物耐药性的遗传基础对于有效控制结核病至关重要.
研究的目的:
- 确定印度奥迪沙州耐异酸结核病 (Hr-TB) 的流行率.
- 确定与Hr-TB相关的katG和inhA基因中常见的突变.
- 探索已识别的突变的治疗影响.
主要方法:
- 从2019年1月到12月的线索探测试 (LPA) 数据的回顾性分析.
- 数据来自印度奥迪沙州的8个地区.
- 对对异尼抗结核病菌株 katG 和 inhA 基因突变的分析.
主要成果:
- 霍氏结核的总体患病率为1.53% (50/3272例).
- 患病率在各个地区各不相同,从0%到3.4%不等.
- 在50种Hr-TB菌株中,74%发现katG突变 (S315T1),26%发现inHA突变 (C15T).
结论:
- 该研究确定了印度奥迪沙州Hr-TB的显著流行率.
- 在katG (S315T1) 和inhA (C15T) 中的特定突变与异化耐药性密切相关.
- 这些发现对该地区治疗耐药结核病有直接的治疗意义.
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