一项为期八年的关于抗微生物耐药性演变的研究,该研究对未经抗微生物治疗的创伤人群进行了研究
Mamta Puraswani1, Sharad Srivastav1, Richa Aggrawal2
1Department of Laboratory Medicine, JPNA Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Indian journal of medical microbiology
|June 25, 2023
概括
医疗相关感染 (HAI) 是重症监护室 (ICU) 的一个主要问题. 这项研究跟踪了8年来ICU中的抗菌素耐药性 (AMR) 模式,揭示了指导治疗和感染控制的趋势.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 医疗相关感染 (HAI) 显著导致疾病和死亡,特别是在低收入和中等收入国家 (LMICs).
- 重症监护室 (ICU) 患者面临更高的HAI风险,需要长期监测抗菌素耐药性 (AMR) 模式.
- 了解AMR的演变对于调整治疗策略和加强感染控制措施至关重要.
研究的目的:
- 在一级创伤中心的ICU中,分析8年来不断演变的抗微生物耐药性 (AMR) 模式.
- 根据局部耐药性趋势,提供数据来修改经验性抗生素处方实践.
- 在ICU环境中提供信息并加强感染控制策略.
主要方法:
- 对2012年1月至2019年12月抗菌素耐药性 (AMR) 监测数据的回顾性分析.
- 包括患者的隔离物被录入1级创伤中心的ICU.
- 使用标准的HAI定义和WHONET软件进行疫情分析.
主要成果:
- 总共分析了来自1969名患者的4305个分离样本.
- 格拉姆阴性细菌,特别是*Acinetobacter baumannii*,*Klebsiella pneumoniae*和*Pseudomonas aeruginosa*,是最常见的生物体.
- 确定了7个疫情/感染群,主要发生在每年10月至12月之间,表明季节性模式.
结论:
- 该研究强调了ICU内抗菌素耐药性 (AMR) 的日益增长趋势.
- 持续的AMR监测和强有力的感染控制实践对于打击日益增长的抗药性至关重要.
- 对抗生素处方进行数据驱动的调整对于有效的患者管理至关重要.
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